Volume 7

Number 2, July 2025

Hepatitis A Virus-Induced Macrophage Activation Syndrome in a Child: A Case Report

DOI: https://doi.org/10.47648/zhswmcj.2025.v0702.08

Munmun FR1 , Nessa L2 , Sultana K3 , Patwary MSA4 , Hossain K5 , Rasna EH6

Abstract

Macrophage activation syndrome (MAS) is characterized by high fever, hepatosplenomegaly, lymphadenopathy, cytopenia, liver dysfunction, and coagulopathy. MAS is a group of hemophagocytic disorders that can be primary or secondary. Primary hemophagocytic lymphohistiocytosis (HLH) is due to an underlying genetic abnormality. Secondary HLH is commonly associated with autoimmune diseases, malignancies, or infections. Although the incidence of hepatitis A virus (HAV) is high in children, there are few cases reports of HAV-associated hemophagocytic syndrome.

Keywords: Macrophage activation syndrome (MAS), Hemophagocytic lymphohistiocytosis (HLH), Hepatitis A


  1. Assistant Professor, Paediatric Gastroenterology and Nutrition

    DMCH

  2. Professor and Head, Department of Paediatrics

    DMCH

  3. Associate Professor, Paediatric Gastroenterology and Nutrition

    DMCH

  4. Associate Professor, Department of Medicine

    DMCH

  5. Junior Consultant, Paediatric Gastroenterology and Nutrition

    DMCH

  6. Registrar, Paediatric Gastroenterology and Nutrition

    DMCH

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Volume 7, Number 2, July 2025
Page: 44-46