Volume 7

Number 1, January 2025

Utilization Patterns of Antimicrobials at a Tertiary Care Hospital’s Intensive Care Unit

DOI: https://doi.org/10.47648/zhswmcj.2025.v0701.01

Chowdhury MJ1 , Faruque CMO2 , Dutta SS3 , Deb K4 , Chowdhury NA5 , Kashem FB6 , Nurunnabi M7

Abstract

Introduction: Antimicrobials are readily prescribed to seriously ill patients, accounting for a large portionof the drugs administered in intensive care units (ICU). Objective: Aimed to explore the antibiotic usagepatterns in the ICU patients of a tertiary care hospital, Sylhet MAG Osmani Medical College Hospital.Methods: A hospital-based retrospective observational study was conducted to explore the pattern of usageof antibiotics in the ICU of Sylhet MAG Osmani Medical College Hospital. The medical records of 530patients admitted to the ICU from July 2020 to June 2021 were reviewed. Results: Antibiotic treatmentwas given to 94.0% of the ICU patients. A culture sensitivity test was done in 72.1% of patients; bloodsamples were more frequently cultured (42.0%). 412 (95.2%) of the 433 samples showed a positive cultureresult. Klebsiella made up 33.3% of the isolated organism. The mean amount of antimicrobials given perpatient was 2.5±1.4. Cephalosporin (38.8%), Carbapenem (31.3%), and Penicillin (29.0%) were the mostcommonly given antimicrobial groups. About half of the patients (50.8%) received multiple antibiotics.The most frequently used drug combinations were Ceftriaxone and Metronidazole, which were given to48.0% of the patients. Conclusion: Cephalosporin and Carbapenem were most frequently utilized asantibacterial agents in this ICU. However, due to the rise of resistance, physicians should be moreaware of using these drugs.

Keywords: Antimicrobial agents, Cephalosporins, Carbapenem, ICU patients, Sylhet.


  1. Associate Professor, Department of Pharmacology and Therapeutics

    Sylhet Women's Medical College, Sylhet

  2. Assistant Professor, Department of Cardiology

    Sylhet MAG Osmani Medical College Hospital, Sylhet

  3. Assistant Professor, Department of Dermatology and Venereology

    Sylhet MAG Osmani Medical College Hospital, Sylhet

  4. Associate Professor, Department of Forensic Medicine and Toxicology

    Sylhet Women's Medical College, Sylhet

  5. Assistant Professor, Department of Pharmacology and Therapeutics

    Sheikh Hasina Medical College, Habiganj, Sylhet

  6. Assistant Professor, Department of Pharmacology and Therapeutics

    Sylhet MAG Osmani Medical College Hospital, Sylhet

  7. Assistant Professor, Department of Community Medicine and Public Health

    Sylhet Women's Medical College, Sylhet

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Volume 7, Number 1, January 2025
Page: 4-11