A Study on Helicobacter pylori Stool Antigen Test and Rapid Urease Test for PUD

DOI: https://doi.org/10.47648/zhswmcj.2022.v0401.04

Md. Nazrul Islam Chowdhury1 , Syeed Mehbub Ul Kadir2 , Qamrun Naher3 , Md. Feroz Khan4 , Lokesh Chakraborty5 , Mohammad Shahadat Hossain6 , Md. Mamun-Ar-Rashid7 , Shaikh Badiuzzaman8


H. pylori infection is an important medical problem in the whole world including Bangladesh. Diagnosis of the disease remains dormant. H. pylori are also related to gastric carcinoma. Early detection of H. pylori is very much important for diagnosis of the disease and successful treatment. The most reliable the non-invasive test is urea breath test. Still the test is not currently available in our country. So, it becomes necessary to validate another reliable modality of noninvasive test. To evaluate the relatively new monoclonal stool antigen test for identification of H. pylori infection in patients with peptic ulcer disease both before and after eradication therapy. And also to compare the stool antigen test with rapid urease test and histopathology of endoscopic biopsy. This quasi study was carried in a clinical pathology department of a tertiary level hospital. We included all patients with peptic ulcer disease those who were diagnosed by upper GIT endoscopy. Demographic variables and value of laboratory test including Stool antigen test, rapid urease test were studied in this study. Out of 86 patients with peptic ulcer disease, male was 65% and female was 35%. The mean age of the study subjects was 38.53 years. The true positive SAT was 63 (73.3%), false negative was 11.6%. The positive predictive values and accuracy of SAT with Histopathology were 95.45%, and 82.56% respectively. The result was statistically highly significant. Stool antigen test (SAT) is an early effective diagnostic tool like other methods for the diagnosis of H. pylori infection in our country. As the test is noninvasive, easy to perform, requiring short time and cost effective, this test will be popular to both patient and physician.

Keywords: Peptic ulcer disease, stool antigen test, rapid urease test, endoscopy, pathology.

  1. Assistant Professor (Clinical Path.)

    National Institute of Ophthalmology, Dhaka

  2. Assistant Professor (Ophth.)

    Sheikh Fazilatunnessa Mujib Eye Hospital and Training Institute, Gopalgonj

  3. Consultant Sonologist

    Medinova Medical Service and Lab Aid Diagnostic Ltd. Dhaka

  4. Associate Professor (Ophth.)

    Z H Sikder Women's Medical College, Dhaka

  5. Assistant Professor (Clinical Path.)

    National Institute of ENT, Dhaka

  6. Emergency Medical Officer

    300 Beded General Hospital, Narayanganj

  7. Junior consultant (Pathology)

    300 beded General Hospital, Narayanganj

  • Assistant Professor (Clinical Path.)

    National Institute of Laboratory Medicine, Dhaka

  • Volume 4, Number 1, January 2022
    Page: 18-21