Volume 5Number 1, January 2023
Comparative study of efficacy of Terbinafine 500mg vs Terbinafine 250mg and Itraconazole 200mg in the treatment of dermatophytosis
Mohsena Akter1 , Md. Abdulla-Hel Kafi2 , Syed Shair Ahmed3 , Ishrat Bhuiyan4
Background: Now a days superficial fungal infections become endemic in a hot humid region/tropic region like Bangladesh. In outpatient department of dermatology most of the patients come with dermatophytic infection. Most of them are maltreated or inadequately treated. We, dermatologist, are facing difficulties in treating these patients.
Materials and Methods: In this study, we tried to find out the effective doses and duration of antifungal drugs Terbinafine and Itraconazole.
Result: Total 92 patients with dermatophytosis of either sex aged 22-60years without any significant systemic diseases were included in this study. The patients were randomly divided into two groups; Group A and Group B. Group A was treated with Terbinafine 500mg daily and Group B was treated with combination of Terbinafine 250 mg & Itraconazole 200mg daily. Duration of treatment was for 6weeks.Itraconazole and Terbinafine containing combined groups showed significantly higher cure rates than terbinafine only groups both at 4 and 8 weeks (P < 0.001).
Conclusion: combination of daily Terbinafine 250mg with Itraconazole 200mg was more efficacious than Terbinafine 500mg
Keywords: Dermatophytosis, Terbinafine, Itraconazole
- Assistant Professor, Department of Dermatology
- Professor & Head of the Department of Dermatology
- Assistant registrar,Department of Dermatology
- Associate Professor & Head of Department of Dermatology & Venereology